BPDE metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC. Its diol epoxide metabolites (more commonly known as BPDE) react and bind to DNA, resulting in mutations and eventually cancer. There are indications that benzo[a]pyrene diol epoxide specifically targets the protective p53 gene. This gene is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor.
All of us are polluted with these agents through air pollution or by consuming the baked food such as grilled chicken, red meat and carbon deposited food items. Hence, BPDE metabolites will cause more harmful by damaging our DNA and eventually causing cancer.
The best way to get to know the content of this harmful chemical which is BPDE is by doing the IBP screening and it can direct you in a right path and through the correct diet couple with other parameters you can easily achieve the healthier lifestyle.